ABSTRACT
AIMS: To examine the association of birth-related factors with diabetes risk in offspring.
METHODS: We evaluated the relationship between maternal age, maternal parity and birth
weight with diabetes in offspring using a case–control design and conditional logistic
regression. Administrative databases linked to vital statistics identified 1366 First
Nations people (FN) with diabetes and 1366 other Saskatchewan residents (OSK) with
diabetes for comparison with their nondiabetic counterparts.
RESULTS: In final models, each 1 kg increase in birth weight elevated diabetes risk
among FN (OR 1.23, 95% CI 1.01-1.50) and OSK (OR 1.16, 95% CI 0.98-1.38) offspring.
Among FN, advancing maternal age interacted with offspring sex to increase diabetes
risk 4% per year for males (OR 1.04, 95% CI 1.01-1.06) and 8% per year for females
(OR 1.08; 95% CI 1.06-1.10). Each year of maternal age increased diabetes risk among
OSK offspring in an interaction with maternal parity (OR 1.09, 95% CI 1.06-1.11 for
parity 1–4; OR 1.04, 95% CI 1.001-1.08 for parity >5).
CONCLUSIONS: The combination of increasing maternal age and birth weight were predictors
for diabetes, particularly in female FN offspring. This is consistent with a diabetogenic
effect of diabetic pregnancies, since both variables are independently associated
with maternal gestational diabetes, intergenerational, intragenerational, maternal
age, maternal parity, Registered Indians, type 2 diabetes.
RÉSUMÉ
OBJECTIF : Examiner le lien entre des facteurs associes a la naissance et le risque
de diabete chez les descendants.
METHODES : Nous avons mene une etude cas temoins avec regression logistique conditionnelle
pour evaluer le rapport entre le diabete et l'age maternel, la parite maternelle et
le poids de naissance. Des bases de donnees administratives en lien avec les statistiques
de l'etat civil ont permis de reperer 1366 membres des Premieres nations (MPN) atteints
de diabete et 1366 autres residants de la Saskatchewan (ARS) atteints de diabete en
vue d'une comparaison avec des personnes ne souffrant pas de diabete.
RESULTATS : Dans les modeles finals, pour chaque kilogramme d'augmentation du poids
de naissance, il y avait une augmentation du risque de diabete chez les descendants
des MPN (RC : 1,23; IC de 95 % : 1,01-1,50) et des ARS (RC : 1,16; IC de 95 % : 0,98-1,38).
Parmi les MPN, il y avait un lien entre l'age maternel et le risque de diabete chez
les descendants : ce risque augmentait de 4 % par annee d'age maternel chez les descendants
de sexe masculin (RC : 1,04; IC de 95 % : 1,01-1,06) et de 8 % par annee d'age maternel
chez les descendants de sexe feminin (RC : 1,08; IC de 95 % : 1,06-1,10). Chaque annee
d'age maternel augmentait le risque de diabete chez les descendants des ARS en fonction
de la parite de la mere (RC : 1,09; IC de 95 % : 1,06-1,11 quand la mere avait eu
entre 1 et 4 enfants; RC : 1,04; IC de 95 % : 1,001-1,08 quand la mere avait eu plus
de 5 enfants).
CONCLUSIONS : La combinaison d'un age maternel eleve et d'un poids de naissance eleve
etait un predicteur de diabete, surtout chez les descendants de sexe feminin des MPN.
Cette observation est conforme avec l'effet diabetogene de la grossesse diabetique,
car les deux variables sont independamment associees au diabete gestationnel chez
la mere.
MOTS CLES : poids de naissance, age maternel, parite maternelle, diabete de type 2,
Autochtone, Indiens inscrits, Premieres nations, grossesse diabetique, diabete gestationnel,
intergenerationnel, intragenerationnel, origines foe tales du diabete
KEYWORDS
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