Abstract| Volume 36, ISSUE 5, SUPPLEMENT , S69, October 2012

Early Overnutrition Impairs Arginine Responsivity in Diabetes-Susceptible Swiss Webster Mice

      Childhood obesity and rapid early growth increase the risk for type 2 diabetes. Such early overnutrition can be modelled in mice by reducing litter size, which results in rapid weight gain, hyperinsulinemia and hyperleptinemia in early life. We have previously demonstrated that such chronic postnatal overnutrition (CPO) in Swiss Webster mice significantly increases susceptibility to diabetes, characterized by profound hyperglycemia and subsequent beta-cell failure. In the present studies we examined whether CPO mice exhibit altered responsivity to glucose and/or arginine in isolated islets prior to the onset of hyperglycemia.
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