Childhood obesity and rapid early growth increase the risk for type 2 diabetes. Such
early overnutrition can be modelled in mice by reducing litter size, which results
in rapid weight gain, hyperinsulinemia and hyperleptinemia in early life. We have
previously demonstrated that such chronic postnatal overnutrition (CPO) in Swiss Webster
mice significantly increases susceptibility to diabetes, characterized by profound
hyperglycemia and subsequent beta-cell failure. In the present studies we examined
whether CPO mice exhibit altered responsivity to glucose and/or arginine in isolated
islets prior to the onset of hyperglycemia.
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© 2012 Published by Elsevier Inc.
