Advertisement

Visceral Adiposity and The Relationship Between Vitamin D and Adiponectin

      Vitamin D status [circulating 25-hydroxyvitamin D (25OHD) concentrations] and adiponectin concentrations are inversely associated with visceral adiposity and risk for cardiovascular disease but the relationship between these two factors is unknown. A few studies have reported a positive association between circulating 25OHD and adiponectin concentrations, however, these studies did not account for visceral adiposity. The goal of this study is to determine the effect of visceral adiposity on the relationship between plasma 25OHD and total and high molecular weight (HMW) adiponectin concentrations in 334 European and South Asian adults. Fifty three percent (53%) of subjects had plasma 25OHD concentrations ≥ 50nmol/L (sufficient) and 47% of subjects had plasma 25OHD concentrations < 50nmol/L (insufficient). Plasma 25OHD concentrations were positively associated with total (r=0.140, p=0.010) and HMW (r=0.117, p=0.034) adiponectin concentrations. After adjusting for age and sex, plasma total adiponectin concentrations in subjects with insufficient 25OHD were 10% lower compared to subjects with sufficient 25OHD [B (95%CI)=-0.104 (-0.187, -0.0125), standardized B= -0.105, p=0.028]. Similarly, subjects with insufficient 25OHD had 21% lower HMW adiponectin concentrations compared to subjects with sufficient 25OHD [B (95%CI)=-0.206 (-0.321, -0.072), standardized B=-0.136, p=0.004]. However, when regression models were adjusted for visceral adipose tissue the effect of 25OHD insufficiency on plasma total and HMW adiponectin concentrations was no longer significant. These findings suggest that the relationship between plasma 25OHD and total and HMW adiponectin concentrations is dependent on visceral adiposity.