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Effect of Lactobacillus Rhamnosus CGMCC1.3724 Supplementation on Weight loss and Maintenance in Obese Men and Women

      Objective

      This study investigated the impact of a Lactobacillus rhamnosus CGMCC1.3724 (LPR) supplementation on weight loss and maintenance in obese men (n=45) and women (n=61) over 24 weeks.

      Design

      In a double blind, placebo-controlled, randomized trial, each subject consumed 2 capsules per day of either a placebo (310 mg of maltodextrin) or a probiotic formulation (10 mg of LPR equivalent to 1.6 108 cfu/capsule, 210 mg of oligofructose and 90 mg of inulin).

      Method

      Each group was submitted to a moderate energy restriction (-500 kcal/day) for the first 12 weeks followed by 12 weeks of weight maintenance. Body weight and composition (DEXA) were measured at baseline, 12 and 24 weeks.

      Results

      Intent-to-treat analysis showed that after 24 weeks mean weight loss for women in the LPR probiotic group was significantly higher than in the placebo group (-5.2 ± 4.0 vs -2.5 ± 3.5 kg; p=0.02, respectively) whereas it was similar in the two groups of men (-5.4 ± 4.8 vs -5.7 ± 4.5 kg; p=0,83, respectively). Furthermore, after 24 weeks mean fat mass loss for women in the LPR probiotic group was significantly higher than in the placebo group (-4.79 ± 3.60 vs -2.16 ± 4.11 kg; p=0.01, respectively) while it was similar in the two groups of men (-4.30 ± 4.14 vs -4.43 ± 3.45 kg; p=0,81, respectively).

      Conclusion

      This study showed that the Lactobacillus rhamnosus CGMCC1.3724 formulation helped obese women to achieve sustainable weight loss.