Abstract
Objective
Many studies have reported the relationship between depression and diabetes, but the
results have been inconsistent. Our aim was to conduct a systematic review through
meta-analysis to assess the association of depression with the risk for developing
diabetes.
Methods
We retrieved the studies concerning depression and the risk for diabetes. Meta-analysis
was applied to calculate the combined effect values and their 95% confidence intervals.
The risk for publication bias was assessed by the Egger regression asymmetry test.
Results
As many as 33 articles were included in the meta-analysis, for a total of 2 411 641
participants. The pooled relative risk for diabetes was 1.41 (95% CI, 1.25–1.59) for
depression, and the combined relative risk for type 2 diabetes mellitus was 1.32 (95%
CI, 1.18–1.47).
Conclusions
Depressed people have a 41% increased risk for developing diabetes mellitus and a
32% increased risk for developing type 2 diabetes. The mechanisms underlying this
relationship are still unclear and need further research.
Résumé
Objectif
De nombreuses études ont rapporté le lien entre la dépression et le diabète, mais
les résultats sont apparus contradictoires. Notre objectif était de mener une revue
systématique par le recours à la méta-analyse pour évaluer le lien entre la dépression
et le risque de développement du diabète.
Méthodes
Nous avons extrait les études concernant la dépression et le risque de diabète. Nous
avons eu recours à la méta-analyse pour calculer les valeurs de l’effet combiné et
leurs intervalles de confiance à 95 %. Le risque de biais de publication a été évalué
à l’aide du test de régression d’Egger.
Résultats
La méta-analyse comportait 33 articles, soit un total de 2 411 641 participants. Lors
de dépression, le risque relatif global du diabète était de 1,41 (IC à 95%, 1,25–1,59)
et le risque relatif combiné de diabète sucré de type 2 était de 1,32 (IC à 95 %,
1,18–1,47).
Conclusions
Les personnes dépressives montrent une augmentation du risque de développement du
diabète sucré de 41 % et une augmentation du risque de développement du diabète de
type 2 de 32 %. Les mécanismes sous-jacents à ce lien ne sont pas encore élucidés.
D’autres recherches sont nécessaires.
Keywords
Mots clés
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Article info
Publication history
Published online: March 14, 2015
Accepted:
November 28,
2014
Received in revised form:
November 28,
2014
Received:
April 24,
2014
Identification
Copyright
© 2015 Canadian Diabetes Association. Published by Elsevier Inc. All rights reserved.
