Abstract
Objective
To examine the associations between elevated levels of C-reactive protein (CRP), soluble
intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin) with
fasting and 2-hour postload glucometabolic status among Inner Mongolians in China.
Methods
Based on a cross-sectional survey of patients during 2003, 2260 participants were
reinvestigated between 2013 and 2014. We categorized the participants into 3 subgroups
according to fasting and postload glucose levels, respectively. The associations between
biomarkers of inflammation and endothelial dysfunction and deterioration of fasting
and postload glucometabolic status were examined by ordinal logistic regression analysis.
Results
We found 142 and 49 persons who had impaired fasting glucose (IFG) levels and type
2 diabetes in the fasting state and 335 and 50 persons who had impaired glucose tolerance
(IGT) and type 2 diabetes in the postload state. After multivariable adjustment, elevated
CRP and sICAM-1 levels were associated with deterioration of fasting glucometabolic
status from normal fasting glucose to IFG and type 2 diabetes (odds ratio [OR] 1.73
[95% CI 1.18 to 2.54] for elevated CRP levels, OR 1.86 [95% CI 1.30 to 2.66] for elevated
sICAM-1 levels). Elevated sE-selectin levels were associated with deterioration of
postload glucometabolic status from normal glucose tolerance to IGT and type 2 diabetes
(OR 1.34 [95% CI 1.01 to 1.77]) in the multivariable-adjusted model.
Conclusions
Biomarkers of inflammation and endothelial dysfunction were separately associated
with fasting and postload glucose metabolism among Inner Mongolians.
Résumé
Objectif
Examiner les associations entre des niveaux élevés de protéine C-réactive (CRP), de
la fraction soluble de la molécule d'adhésion intercellulaire de type 1 (sICAM-1),
et de la fraction soluble de la E-sélectine (sE-sélectine) avec le statut gluco-métabolique
à jeûn et 2 heures postprandial chez une population de Mongolie Intérieure en Chine.
Méthodes
Basé sur une enquête transversale sur des patients en 2003, 2260 participants ont
été ré-évalués entre 2013 et 2014. Nous avons classé les participants en 3 sous-groupes
en fonction des niveaux de jeûne et de glycémie postprandiale, respectivement. Les
associations entre les biomarqueurs de l'inflammation et la dysfonction endothéliale,
ainsi que la dégradation des statuts gluco-métaboliques à jeun et postprandial ont
été examinés via une analyse par régression logistique ordinale.
Résultats
Nous avons trouvé 142 et 49 personnes qui avaient des niveaux de glucose à jeun altérés
(IFG) et un diabète de type 2 lors du jeûne, et 335 et 50 personnes qui avaient une
intolérance au glucose (IGT) et un diabète de type 2 à l'état postprandial. Après
ajustement par analyse multivariée, des niveaux élevés de CRP et de sICAM-1 ont été
associés à une altération du statut de l'état gluco-métabolique lors du jeûne d'une
glycémie à jeun normale à un IFG et un diabète de type 2 (odds ratio [OR] 1,73 [IC
95% 1.18 à 2,54] pour les niveaux de CRP élevés, OR 1,86 [IC 95% atteindre 1,30 à
2,66] pour les niveaux élevés de sICAM-1). Dans le modèle multivarié ajusté, des niveaux
élevés de sE-sélectine ont été associés à une altération de l'état gluco-métabolique
postprandial d'une normo-tolérance au glucose à une IGT et un diabète de type 2 (OR
1,34 [IC 95% 1,01 à 1,77]).
Conclusions
Les biomarqueurs de l'inflammation et de la dysfonction endothéliale ont été séparément
associés au métabolisme du glucose à jeun et en état postprandial parmi la population
de Mongolie Intérieure.
Keywords
Mots clés
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Article info
Publication history
Published online: July 04, 2016
Accepted:
April 13,
2016
Received in revised form:
March 30,
2016
Received:
January 22,
2016
Identification
Copyright
© 2016 Canadian Diabetes Association.