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Association of Biomarkers of Inflammation and Endothelial Dysfunction with Fasting and Postload Glucose Metabolism: A Population-Based Prospective Cohort Study Among Inner Mongolians in China

  • Author Footnotes
    1 These authors contributed to this work equally.
    Jiahui Wu
    Footnotes
    1 These authors contributed to this work equally.
    Affiliations
    Department of Epidemiology, School of Public Health, Medical College of Soochow University, Jiangsu, China
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  • Author Footnotes
    1 These authors contributed to this work equally.
    Zhu Liang
    Footnotes
    1 These authors contributed to this work equally.
    Affiliations
    Department of Epidemiology, School of Public Health, Medical College of Soochow University, Jiangsu, China
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  • Jingwen Zhou
    Affiliations
    Department of Epidemiology, School of Public Health, Medical College of Soochow University, Jiangsu, China
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  • Chongke Zhong
    Affiliations
    Department of Epidemiology, School of Public Health, Medical College of Soochow University, Jiangsu, China
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  • Wei Jiang
    Affiliations
    Department of Epidemiology, School of Public Health, Medical College of Soochow University, Jiangsu, China
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  • Yonghong Zhang
    Affiliations
    Department of Epidemiology, School of Public Health, Medical College of Soochow University, Jiangsu, China

    Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, China
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  • Shaoyan Zhang
    Correspondence
    Address for correspondence: Shaoyan Zhang, MD, PHD, Department of Epidemiology, School of Public Health, Medical College of Soochow University, 199 Renai Road, Industrial Park District, Suzhou 215123, China.
    Affiliations
    Department of Epidemiology, School of Public Health, Medical College of Soochow University, Jiangsu, China

    Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, China
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  • Author Footnotes
    1 These authors contributed to this work equally.

      Abstract

      Objective

      To examine the associations between elevated levels of C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin) with fasting and 2-hour postload glucometabolic status among Inner Mongolians in China.

      Methods

      Based on a cross-sectional survey of patients during 2003, 2260 participants were reinvestigated between 2013 and 2014. We categorized the participants into 3 subgroups according to fasting and postload glucose levels, respectively. The associations between biomarkers of inflammation and endothelial dysfunction and deterioration of fasting and postload glucometabolic status were examined by ordinal logistic regression analysis.

      Results

      We found 142 and 49 persons who had impaired fasting glucose (IFG) levels and type 2 diabetes in the fasting state and 335 and 50 persons who had impaired glucose tolerance (IGT) and type 2 diabetes in the postload state. After multivariable adjustment, elevated CRP and sICAM-1 levels were associated with deterioration of fasting glucometabolic status from normal fasting glucose to IFG and type 2 diabetes (odds ratio [OR] 1.73 [95% CI 1.18 to 2.54] for elevated CRP levels, OR 1.86 [95% CI 1.30 to 2.66] for elevated sICAM-1 levels). Elevated sE-selectin levels were associated with deterioration of postload glucometabolic status from normal glucose tolerance to IGT and type 2 diabetes (OR 1.34 [95% CI 1.01 to 1.77]) in the multivariable-adjusted model.

      Conclusions

      Biomarkers of inflammation and endothelial dysfunction were separately associated with fasting and postload glucose metabolism among Inner Mongolians.

      Résumé

      Objectif

      Examiner les associations entre des niveaux élevés de protéine C-réactive (CRP), de la fraction soluble de la molécule d'adhésion intercellulaire de type 1 (sICAM-1), et de la fraction soluble de la E-sélectine (sE-sélectine) avec le statut gluco-métabolique à jeûn et 2 heures postprandial chez une population de Mongolie Intérieure en Chine.

      Méthodes

      Basé sur une enquête transversale sur des patients en 2003, 2260 participants ont été ré-évalués entre 2013 et 2014. Nous avons classé les participants en 3 sous-groupes en fonction des niveaux de jeûne et de glycémie postprandiale, respectivement. Les associations entre les biomarqueurs de l'inflammation et la dysfonction endothéliale, ainsi que la dégradation des statuts gluco-métaboliques à jeun et postprandial ont été examinés via une analyse par régression logistique ordinale.

      Résultats

      Nous avons trouvé 142 et 49 personnes qui avaient des niveaux de glucose à jeun altérés (IFG) et un diabète de type 2 lors du jeûne, et 335 et 50 personnes qui avaient une intolérance au glucose (IGT) et un diabète de type 2 à l'état postprandial. Après ajustement par analyse multivariée, des niveaux élevés de CRP et de sICAM-1 ont été associés à une altération du statut de l'état gluco-métabolique lors du jeûne d'une glycémie à jeun normale à un IFG et un diabète de type 2 (odds ratio [OR] 1,73 [IC 95% 1.18 à 2,54] pour les niveaux de CRP élevés, OR 1,86 [IC 95% atteindre 1,30 à 2,66] pour les niveaux élevés de sICAM-1). Dans le modèle multivarié ajusté, des niveaux élevés de sE-sélectine ont été associés à une altération de l'état gluco-métabolique postprandial d'une normo-tolérance au glucose à une IGT et un diabète de type 2 (OR 1,34 [IC 95% 1,01 à 1,77]).

      Conclusions

      Les biomarqueurs de l'inflammation et de la dysfonction endothéliale ont été séparément associés au métabolisme du glucose à jeun et en état postprandial parmi la population de Mongolie Intérieure.

      Keywords

      Mots clés

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      References

        • Duncan B.B.
        • Schmidt M.I.
        • Pankow J.S.
        • et al.
        Low-grade systemic inflammation and the development of type 2 diabetes: The atherosclerosis risk in communities study.
        Diabetes. 2003; 52: 1799-1805
        • Pan X.R.
        • Yang W.Y.
        • Li G.W.
        • et al.
        Prevalence of diabetes and its risk factors in China, 1994. National Diabetes Prevention and Control Cooperative Group.
        Diabetes Care. 1997; 20: 1664-1669
        • Dong Y.
        • Gao W.
        • Nan H.
        • et al.
        Prevalence of type 2 diabetes in urban and rural Chinese populations in Qingdao, China.
        Diabet Med. 2005; 22: 1427-1433
        • Xu Y.
        • Wang L.
        • He J.
        • et al.
        Prevalence and control of diabetes in Chinese adults.
        JAMA. 2013; 310: 948-959
        • Hu F.B.
        • Meigs J.B.
        • Li T.Y.
        • et al.
        Inflammatory markers and risk of developing type 2 diabetes in women.
        Diabetes. 2004; 53: 693-700
        • Han T.S.
        • Sattar N.
        • Williams K.
        • et al.
        Prospective study of C-reactive protein in relation to the development of diabetes and metabolic syndrome in the Mexico City Diabetes Study.
        Diabetes Care. 2002; 25: 2016-2021
        • Krakoff J.
        • Funahashi T.
        • Stehouwer C.D.
        • et al.
        Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima Indian.
        Diabetes Care. 2003; 26: 1745-1751
        • Stranges S.
        • Rafalson L.B.
        • Dmochowski J.
        • et al.
        Additional contribution of emerging risk factors to the prediction of the risk of type 2 diabetes: Evidence from the Western New York Study.
        Obesity (Silver Spring). 2008; 16: 1370-1376
        • Song Y.
        • Manson J.E.
        • Tinker L.
        • et al.
        Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women.
        Diabetes. 2007; 56: 1898-1904
        • Abdul-Ghani M.A.
        • Jenkinson C.P.
        • Richardson D.K.
        • et al.
        Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: Results from the Veterans Administration Genetic Epidemiology Study.
        Diabetes. 2006; 55: 1430-1435
        • Thompson A.M.
        • Zhang Y.
        • Tong W.
        • et al.
        Association of obesity and biomarkers of inflammation and endothelial dysfunction in adults in Inner Mongolia, China.
        Int J Cardiol. 2011; 150: 247-252
        • Xu T.
        • Bu X.Q.
        • Li H.M.
        • et al.
        Smoking, heart rate, and ischemic stroke a population-based prospective cohort study among Inner Mongolians in China.
        Stroke. 2013; 44: 2457-2461
        • Friedewald W.T.
        • Levy R.I.
        • Fredrickson D.S.
        Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.
        Clin Chem. 1972; 18: 499-502
        • Haber E.
        • Koerner T.
        • Page L.B.
        • et al.
        Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects.
        J Clin Endocrinol Metab. 1969; 29: 1349-1355
        • Ridker P.M.
        C-Reactive protein and the prediction of cardiovascular events among those at intermediate risk: Moving an inflammatory hypothesis toward consensus.
        J Am Coll Cardiol. 2007; 49: 2129-2138
        • Doi Y.
        • Kiyohara Y.
        • Kubo M.
        • et al.
        Elevated C-reactive protein is a predictor of the development of diabetes in a general Japanese population: The Hisayama Study.
        Diabetes Care. 2005; 28: 2497-2500
        • Thorand B.
        • Baumert J.
        • Kolb H.
        • et al.
        Sex differences in the prediction of type 2 diabetes by inflammatory markers: Results from the MONICA/KORA Augsburg case-cohort study, 1984–2002.
        Diabetes Care. 2007; 30: 854-860
        • Aronson D.
        • Bartha P.
        • Zinder O.
        • et al.
        Association between fasting glucose and C-reactive protein in middle-aged subjects.
        Diabet Med. 2004; 21: 39-44
        • Festa A.
        • D'Agostino R.
        • Tracy R.P.
        • et al.
        C-reactive protein is more strongly related to post-glucose load glucose than to fasting glucose in non-diabetic subjects: The Insulin Resistance Atherosclerosis Study.
        Diabet Med. 2002; 19: 939-943
        • Freeman D.J.
        • Norrie J.
        • Caslake M.J.
        • et al.
        C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study.
        Diabetes. 2002; 51: 1596-1600
        • Barzilay J.I.
        • Abraham L.
        • Heckbert S.R.
        • et al.
        The relation of markers of inflammation to the development of glucose disorders in the elderly: The Cardiovascular Health Study.
        Diabetes. 2001; 50: 2384-2389
        • Meigs J.B.
        • Hu F.B.
        • Rifai N.
        • et al.
        Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus.
        JAMA. 2004; 291: 1978-1986
        • Hoogeveen R.C.
        • Ballantyne C.M.
        • Bang H.
        • et al.
        Circulating oxidised low-density lipoprotein and intercellular adhesion molecule-1 and risk of type 2 diabetes mellitus: The Atherosclerosis Risk in Communities Study.
        Diabetologia. 2007; 50: 36-42
        • Oguz E.
        • Tabur S.
        • Akbas H.
        • et al.
        The association of ICAM E469K with cardiovascular characteristics of acromegaly.
        Eur Rev Med Pharmacol Sci. 2015; 19: 1673-1679
        • Tso T.K.
        • Huang W.N.
        Elevated soluble intercellular adhesion molecule-1 levels in patients with systemic lupus erythematosus: Relation to insulin resistance.
        J Rheumatol. 2007; 34: 726-730
        • Kowalska I.
        • Straczkowski M.
        • Szelachowska M.
        • et al.
        Circulating E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in men with coronary artery disease assessed by angiography and disturbances of carbohydrate metabolism.
        Metab Clin Exp. 2002; 51: 733-736
        • Xi L.
        • Xiao C.
        • Bandsma R.H.
        • et al.
        C-reactive protein impairs hepatic insulin sensitivity and insulin signaling in rats: Role of mitogen-activated protein kinases.
        Hepatology. 2011; 53: 127-135
        • Kent J.W.
        • Comuzzie A.G.
        • Mahaney M.C.
        • et al.
        Intercellular adhesion molecule-1 concentration is genetically correlated with insulin resistance, obesity, and HDL concentration in Mexican Americans.
        Diabetes. 2004; 53: 2691-2695
        • Matsumoto K.
        • Sera Y.
        • Nakamura H.
        • et al.
        Serum concentrations of soluble adhesion molecules are related to degree of hyperglycemia and insulin resistance in patients with type 2 diabetes mellitus.
        Diabetes Res Clin Pract. 2002; 55: 131-138
        • Adamska A.
        • Karczewska-Kupczewska M.
        • Nikolajuk A.
        • et al.
        Relationships of serum soluble E-selectin concentration with insulin sensitivity and metabolic flexibility in lean and obese women.
        Endocrine. 2014; 45: 422-429