Sugars have emerged as 1 of the most important public health concerns. Special attention has focused on the fructose moiety of sugars owing to its unique metabolic and endocrinologic responses. Low-quality ecologic studies (
- Bray G.A.
- Nielsen S.J.
- Popkin B.M.
Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity.
Am J Clin Nutr. 2004; 794 (Erratum in Am J Clin Nutr 2004;804:1090): 537-543
- Basu S.
- Yoffe P.
- Hills N.
- Lustig R.H.
The relationship of sugar to population-level diabetes prevalence: An econometric analysis of repeated cross-sectional data.
PLoS ONE. 2013; 82: e57873
3), animal models of overfeeding at levels of exposure far beyond mean population levels of intake (
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High fructose corn syrup and diabetes prevalence: A global perspective.
Glob Pub Health. 2013; 81: 55-64
4) and select human interventions lacking control for energy (
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Is fructose a story of mice but not men?.
J Am Diet Assoc. 2011; 1112: 219-220
5) have been used to implicate fructose-containing sugars in the epidemics of obesity and diabetes. Although experimental models have been invoked to offer plausible biochemical mechanisms to support these positions, whereby fructose acts as an unregulated substrate for de novo lipogenesis, depletes intracellular adenosine triphosphate and impairs satiety signalling through insulin, leptin and ghrelin (
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Obesity (Silver Spring). 2016; 242: 453-460
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Public health: The toxic truth about sugar.
Nature. 2012; 482: 27-29
- Lustig R.H.
Fructose: It's “alcohol without the buzz.”.
Adv Nutr. 2013; 42: 226-235
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Hypothesis: Could excessive fructose intake and uric acid cause type 2 diabetes?.
Endocr Rev. 2009; 301: 96-116
9), the clinical translation of these mechanisms remains in question.
- Johnson R.J.
- Nakagawa T.
- Sanchez-Lozada L.G.
- et al.
Sugar, uric acid, and the etiology of diabetes and obesity.
Diabetes. 2013; 62: 3307-3315
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- Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity.Am J Clin Nutr. 2004; 794 (Erratum in Am J Clin Nutr 2004;804:1090): 537-543
- The relationship of sugar to population-level diabetes prevalence: An econometric analysis of repeated cross-sectional data.PLoS ONE. 2013; 82: e57873
- High fructose corn syrup and diabetes prevalence: A global perspective.Glob Pub Health. 2013; 81: 55-64
- Is fructose a story of mice but not men?.J Am Diet Assoc. 2011; 1112: 219-220
- Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome.Obesity (Silver Spring). 2016; 242: 453-460
- Public health: The toxic truth about sugar.Nature. 2012; 482: 27-29
- Fructose: It's “alcohol without the buzz.”.Adv Nutr. 2013; 42: 226-235
- Hypothesis: Could excessive fructose intake and uric acid cause type 2 diabetes?.Endocr Rev. 2009; 301: 96-116
- Sugar, uric acid, and the etiology of diabetes and obesity.Diabetes. 2013; 62: 3307-3315
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Accepted: May 4, 2016
Received: May 2, 2016
© 2016 Canadian Diabetes Association.
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- Erratum to ‘Sickeningly Sweet: Does Sugar Cause Chronic Disease? No’ (Canadian Journal of Diabetes, Volume 40  Pages 287–295)Canadian Journal of DiabetesVol. 40Issue 6