Sugars have emerged as 1 of the most important public health concerns. Special attention
has focused on the fructose moiety of sugars owing to its unique metabolic and endocrinologic
responses. Low-quality ecologic studies (
1
,
2
,
3
), animal models of overfeeding at levels of exposure far beyond mean population levels
of intake (
4
) and select human interventions lacking control for energy (
5
) have been used to implicate fructose-containing sugars in the epidemics of obesity
and diabetes. Although experimental models have been invoked to offer plausible biochemical
mechanisms to support these positions, whereby fructose acts as an unregulated substrate
for de novo lipogenesis, depletes intracellular adenosine triphosphate and impairs
satiety signalling through insulin, leptin and ghrelin (
6
,
7
,
8
,
9
), the clinical translation of these mechanisms remains in question.To read this article in full you will need to make a payment
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Article info
Publication history
Accepted:
May 4,
2016
Received:
May 2,
2016
Identification
Copyright
© 2016 Canadian Diabetes Association.
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Access this article on ScienceDirectLinked Article
- Erratum to ‘Sickeningly Sweet: Does Sugar Cause Chronic Disease? No’ (Canadian Journal of Diabetes, Volume 40 [2016] Pages 287–295)Canadian Journal of DiabetesVol. 40Issue 6
