Abstract
Background
Gold nanoparticles are known for their many applications in the fields of therapeutics
and diagnosis.
Methods
This article focuses mainly on the green method of synthesizing gold nanoparticles
by using the leaf powder extract of the insulin plant Chamaecostus cuspidatus and on the characterization of developed plant-mediated synthesis of gold nanoparticles.
Furthermore, we investigated the free-radical scavenging activity of green-synthesized
gold nanoparticles.
Results
The free radicals were exhibited in a dose-dependent manner. The 50% inhibition of
free radicals by gold nanoparticles showed that it was similar to that of the standard
inhibition. Toxicity studies generally examine changes in blood serum chemistry and
cell populations in tissue morphology through histologic analysis without inducing
any lethal effects in the mouse model, thereby accomplishing sustained control over
the progression of diabetes mellitus, which plays a leading role in vascular complications
in patients. The treatment by gold nanoparticles of the mice with diabetes for a period
of 21 days restored their blood glucose, glycogen and insulin levels.
Conclusions
The use of gold nanoparticles as antidiabetes materials has been achieved. Further
studies are required before gold nanoparticle–based drugs are more widely used.
Résumé
Contexte
Les nanoparticules d'or sont connues pour leurs nombreuses applications dans les domaines
de la thérapeutique et du diagnostic.
Méthodes
Le présent article porte principalement sur la méthode de synthèse verte des nanoparticules
d'or à partir de la poudre d'extrait de feuilles de la plante d'insuline Chamaecostus cuspidatus et sur la caractérisation de la synthèse médiée par la plante des nanoparticules
d'or. De plus, nous avons examiné l'activité de piégeage des radicaux libres des nanoparticules
d'or synthétisées par la méthode verte.
Résultats
Les radicaux libres ont été exposés de façon proportionnelle à la dose. L'inhibition
de 50 % des radicaux libres par les nanoparticules d'or a montré un résultat similaire
avec l'inhibition habituelle. Les études sur la toxicité visent généralement à examiner
les modifications de la chimie du sérum sanguin et les populations cellulaires dans
la morphologie tissulaire par l'étude histologique sans réduire les effets létaux
dans le modèle de souris, mais pour maîtriser de manière prolongée l'évolution du
diabète sucré, qui joue un rôle prépondérant dans la survenue des complications vasculaires
chez les patients. Le traitement des souris diabétiques par nanoparticules d'or durant
21 jours rétablit leurs concentrations de glucose dans le sang, en glycogène et d'insuline.
Conclusions
L'utilisation des nanoparticules d'or comme matériaux antidiabétiques a été démontrée;
les médicaments à base de nanoparticules d'or seront davantage utilisés s'ils font
l'objet d'autres études.
Keywords
Mots clés
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Article Info
Publication History
Published online: June 06, 2018
Accepted:
May 25,
2018
Received:
August 2,
2017
Footnotes
The Canadian Diabetes Association is the registered owner of the name Diabetes Canada.
Identification
Copyright
© 2018 Canadian Diabetes Association.
