Autophagy helps protect stressed β-cells, but lysosomes and autophagic flux are impaired by severe lipotoxicity or inflammation conditions that activate ER-stress. Transcription factor EB (TFEB) has emerged as a master regulator of lysosomal function and autophagy. Here, we investigate if disruption of TFEB contributes to failure and death of β-cells under various ER stress-inducing conditions.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Canadian Journal of Diabetes
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
© 2019 Published by Elsevier Inc.