Autophagy helps protect stressed β-cells, but lysosomes and autophagic flux are impaired
by severe lipotoxicity or inflammation conditions that activate ER-stress. Transcription
factor EB (TFEB) has emerged as a master regulator of lysosomal function and autophagy.
Here, we investigate if disruption of TFEB contributes to failure and death of β-cells
under various ER stress-inducing conditions.
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© 2019 Published by Elsevier Inc.
