Abstract| Volume 43, ISSUE 7, SUPPLEMENT , S5, October 2019

11 - Investigating the Roles of Transcription Factor EB (TFEB) in β-Cell Function and Survival Under Stress

      Autophagy helps protect stressed β-cells, but lysosomes and autophagic flux are impaired by severe lipotoxicity or inflammation conditions that activate ER-stress. Transcription factor EB (TFEB) has emerged as a master regulator of lysosomal function and autophagy. Here, we investigate if disruption of TFEB contributes to failure and death of β-cells under various ER stress-inducing conditions.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Canadian Journal of Diabetes
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect