Abstract| Volume 43, ISSUE 7, SUPPLEMENT , S5-S6, October 2019

12 - Examining the Role of the HNF-1a G319S Variant in Liver Function and Early-Onset Type 2 Diabetes

      Type 2 diabetes (T2D) diagnoses in Anishininiiwuk (Oji-Cree) linguistic group of northeastern Manitoba and northwestern Ontario are among the highest in the world, and a genetic variant known as HNF-1a G319S in this population has been associated with earlier onset of T2D. Historically, T2D in Anishininiiwuk communities was rare when Anishininiiuk people lived a traditional lifestyle as nomadic hunter-gatherers; a lifestyle associated with long periods of fasting and significant energy exertion. While the G319S variant is currently the strongest genetic predictor of diabetes, it is currently unclear if the G319S variant provides a metabolic advantage in the fasted/starved state.
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