Type 2 diabetes (T2D) diagnoses in Anishininiiwuk (Oji-Cree) linguistic group of northeastern Manitoba and northwestern Ontario are among the highest in the world, and a genetic variant known as HNF-1a G319S in this population has been associated with earlier onset of T2D. Historically, T2D in Anishininiiwuk communities was rare when Anishininiiuk people lived a traditional lifestyle as nomadic hunter-gatherers; a lifestyle associated with long periods of fasting and significant energy exertion. While the G319S variant is currently the strongest genetic predictor of diabetes, it is currently unclear if the G319S variant provides a metabolic advantage in the fasted/starved state.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Canadian Journal of Diabetes
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
© 2019 Published by Elsevier Inc.