Type 2 diabetes (T2D) diagnoses in Anishininiiwuk (Oji-Cree) linguistic group of northeastern
Manitoba and northwestern Ontario are among the highest in the world, and a genetic
variant known as HNF-1a G319S in this population has been associated with earlier
onset of T2D. Historically, T2D in Anishininiiwuk communities was rare when Anishininiiuk
people lived a traditional lifestyle as nomadic hunter-gatherers; a lifestyle associated
with long periods of fasting and significant energy exertion. While the G319S variant
is currently the strongest genetic predictor of diabetes, it is currently unclear
if the G319S variant provides a metabolic advantage in the fasted/starved state.
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© 2019 Published by Elsevier Inc.
