Abstract
Diabetes classification has traditionally considered type 1 and type 2 diabetes as
2 separate entities with different pathogenic mechanisms. However, clinicians and
researchers see increasingly more exceptions to this conventional paradigm, leading
to a concept of mixed phenotypes in diabetes classification. Herein we report the
case of an adolescent with unclear diabetes type due to the presence of obesity, robust
endogenous insulin production, multiple islet autoantibody positivity and severe hyperglycemia
at diabetes diagnosis that has been successfully treated with liraglutide therapy
alone. Our case report highlights the difficulty of diabetes classification and subsequent
need for personalized medicine with regard to diabetes management.
Résumé
D’après la classification traditionnelle du diabète, le diabète de type 1 et de type
2 sont considérés comme 2 entités distinctes dont les mécanismes pathogéniques sont
différents. Toutefois, les cliniciens et les chercheurs voient de plus en plus d’exceptions
à ce paradigme traditionnel, qui les font aboutir à un concept de phénotypes mixtes
lors de la classification du diabète. Dans le présent article, nous rapportons le
cas d’un adolescent atteint d’un type incertain de diabète dû à la présence d’obésité,
de production d’insuline endogène, de positivité à de nombreux anticorps anti-îlots
et d’hyperglycémie grave au moment du diagnostic du diabète, dont le traitement par
liraglutide seul s’est avéré efficace. Notre observation met en évidence la complexité
de la classification du diabète et, par conséquent, la nécessité d’appliquer la médecine
personnalisée lors de la prise en charge du diabète.
Keywords
Mots clés
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Article Info
Publication History
Published online: August 02, 2022
Accepted:
July 20,
2022
Received in revised form:
July 6,
2022
Received:
September 16,
2021
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Canadian Diabetes Association.
