Case Report| Volume 47, ISSUE 2, P190-192, March 2023

Insulin Reactions: What Do You Do When Your Treatment’s the Trigger?

Published:August 29, 2022DOI:
      Insulin hypersensitivity reactions in type 1 diabetes can be severe and are associated with significant short- and long-term morbidity.
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        • Ghazavi M.K.
        • Johnston G.A.
        Insulin allergy.
        Clin Dermatol. 2011; 29: 300-305
        • Brader M.L.
        • Sukumar M.
        • Pekar A.H.
        • et al.
        Hybrid insulin cocrystals for controlled release delivery.
        Nat Biotechnol. 2002; 20: 800-804
        • Heinzerling L.
        • Raile K.
        • Rochlitz H.
        • Zuberbeier T.
        • Worm M.
        Insulin allergy: Clinical manifestations and management strategies.
        Allergy. 2008; 63: 148-155
        • Shimizu I.
        • Furuya K.
        • Odawa H.
        • Fujii Y.
        • Makino H.
        A case of insulin-induced localized lobular panniculitis with evidence for the phagocytosis of insulin by histiocytes.
        Endocr J. 2007; 54: 477-480
        • Koroscil T.
        • Kagzi Y.
        • Zacharias D.
        Failure of multiple therapies in the treatment of a type 1 diabetic patient with insulin allergy: A case report.
        Endocr Pract. 2011; 17: 91-94
        • Heinzerling H.
        Hypersensitivity reactions to insulins.
        in: Adkinson N.F. Nathan D.M. UpToDate. 2021
        • Shapiro A.M.
        • Pokrywczynska M.
        • Ricordi C.
        Clinical pancreatic islet transplantation.
        Nat Rev Endocrinol. 2017; 13: 268-277
        • Pasquini S.
        • Da Prato G.
        • Tonolo J.
        • Bonora J.
        • Trombetta M.
        Continuous intraperitoneal insulin infusion: An alternative route for insulin delivery in type 1 diabetes.
        Acta Diabetol. 2020; 57: 101-104
        • Lee S.I.
        • Narendran P.
        Intraperitoneal insulin therapy for a patient with type 1 diabetes with insulin injection site inflammation.
        BMJ Case Rep. 2014; 2014bcr201405278
        • Accu-Chek
        Continuous intraperitoneal insulin infusion---a valuable option when subcutaneous insulin delivery fails.
        • Dirnena-Fusini I.
        • Kierulf A.
        • Fougner A.L.
        • Carlsen S.M.
        • Christiansen S.C.
        Physiological effects of intraperitoneal versus subcutaneous insulin infusion in patients with diabetes mellitus type 1: A systematic review and meta-analysis.
        PLoS One. 2021; 16e0249611
        • Warrington R.
        • Silviu-Dan F.
        • Wong T.
        Drug allergy.
        Allergy Asthma Clin Immunol. 2018; 14: 60
        • Rieger C.
        • Kurz K.
        • Mueller-Hoffmann W.
        • Gehr B.
        • Leibl A.
        New design of a percutaneous port system for continuous intraperitoneal insulin infusion.
        J Diabetes Sci Technol. 2019; 13: 1158-1160